Blade

Wesley Snipes

Blade

Stephen Dorff

Deacon Frost

Kris Kristofferson

Whistler

N'Bushe Wright

Karen

Donal Logue

Quinn

Udo Kier

Dragonetti

Arly Jover

Mercury

Traci Lords

Racquel

Kevin Patrick Walls

Krieger

Tim Guinee

Curtis Webb

Sanaa Lathan

Vanessa

Eric Edwards

Pearl

Donna Wong

Nurse

Carmen Thomas

Senior Resident

Shannon Lee

Resident

Kenny Johnson

Heatseeking Dennis

Clint Curtis

Creepy Morgue Guy

Judson Scott

Pallantine

Sidney S. Liufau

Japanese Doorman

Keith Leon Williams

Kam

Andray Johnson

Paramedic

Stephen R. Peluso

Paramedic

Marcus Aurelius

Pragmatic Policeman

John Enos III

Blood Club Bouncer

Eboni 'Chrystal' Adams

Martial Arts Kid

Lyle Conway

Reichardt

Freeman White

Menacing Stud

D.V. DeVincentis

Vampire Underling

Marcus Salgado

Frost's Goon

Esau McKnight

Frost's Goon

Erl Van Douglas

Von Esper

Matt Schulze

Crease

Lennox Brown

Pleading Goon

Yvette Ocampo

Party Girl

Irena Stepić

Slavic Vampire Lord

Jenya Lano

Russian Woman

Levan Uchaneishvili

Russian Vampire

Chris Casamassa

Vampire (uncredited)

Ron Cobert

Vampire (uncredited)

Laura Cordova

Vampire (uncredited)